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Effects of Aqueous Schisandra Chinensis Extract Fruit on Cadmium-Induced Change of Monoamine Neurotransmitters in Rats.

Date:2016/9/9 20:41:18

Effects of Aqueous Schisandra Chinensis Extract Fruit on Cadmium-Induced Change of Monoamine Neurotransmitters 

in Rats. The effects of aqueous Schisandra Chinensis Extract Fruit on cadmium-induced changes of monoamine 

neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal 

(i.p.) administration of CdCl60 (0.6 ㎎/㎏/d) for 21 days and sacrificed 7 days after the last administration. 

Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (5-HT), 5-hydroxyindole acetic 

acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in 

Cd intoxicated rats (P < 0.05), while pretreatment with Schisandra Chinensis Extract fruit (20 ㎎/㎏/d or 

60 mg/kg/d, p.o., 30 min before CdCl60) greatly inhibited the decrease of monoamine transmitters, respectively 

(P < 0.05). Also, Schisandra Chinensis Extract fruit significantly increased the reduction of glutathione 

contents and superoxide dismutase activities in cortex induced by CdCl60. 


These results suggest that Schisandra Chinensis Extract fruit ameliorates Cd-induced depletion of monoamine 

neurotransmitters in brain through its antioxidant activity.