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Effects of Schisandra chinensis extract on hemorheology and microcirculation in hyperlipidemia rats.

Date:2016/9/8 22:00:13

Effects of Schisandra chinensis extract on hemorheology and microcirculation in hyperlipidemia rats. Objective 

To observe the effects of Schisandra chinensis extract on hemorheology and microcirculation in hyperlipidemia 

rats. Methods Sixty male Wistar rats were random Ly divided into 6 groups with 10 rats in each group. 


That is,the blank group,model group,control group( Shan Zha Jing Jiang Zhi Pian,24. 3 mg•kg~(-1)),high,medium 

and small dose(Schisandra chinensis extract,60,20,5 mg•kg~(-1)) test groups. One times a day,21 days of continuous 

intragastric administration.


At the beginning of the eighth day,1 times a day, high fat emulsion 0. 01 m L•g~(-1)intragastric administration 

for 14 days( except for the blank group). After 22 days anesthesia,using microcirculation image processing system 

for the observation of mesenteric microcirculation. Blood rheology of carotid artery was determined by blood viscometer. 


Results Compared with the model group,middle,high dose test groups and the control group with micro vein diameter 

[( 14. 86 ± 3. 84),( 14. 23 ± 1. 61),( 14. 05 ± 2. 14) μm ], micro artery iameter [( 9. 60 ± 1. 42),( 9. 43 ± 0. 92),

( 9. 43 ± 0. 77) μm] and the number of capillaries[( 33. 60 ± 5. 12),( 37. 00 ± 2. 28),( 33. 33 ± 3. 30) μm] were 

significantly increased( P 0. 05,P 0. 01). Whole blood viscosity on shear rate were significantly decreased( P 0. 05,P 0. 01).

Conclusion Schisandra chinensis extract can decrease the blood viscosity of whole blood and improve the microcirculation 

of the blood lipid in hyperlipidemia rats. It can play a better role in prevention and treatment of atherosclerosis and hyperlipidemia.