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Schisandra Chinensis Extract Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes in hepatic damage induced rats.

Date:2016/8/31 16:55:50

Schisandra Chinensis Extract Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes 

in hepatic damage induced rats.BACKGROUND/OBJECTIVES: This study investigated the antioxidant activities and 

hepatoprotective effects of Schisandra chinensis extract Baillon extract (SCE) against tert-butyl hydroperoxide (t-BHP)

-induced oxidative hepatic damage in rats. MATERIALS/METHODS: Sprague-Dawley (SD) rats were pretreated with SCE

(300, 600, and 1,200 mg/kg BW) or saline once daily for 14 consecutive days. On day 14, each animal, except 

those belonging to the normal control group, were injected with t-BHP (0.8 mmol/kg BW/i.p.), and all of the 

rats were sacrificed 16 h after t-BHP injection. RESULTS: Although no significant differences in AST and ALT 

levels were observed among the TC and Schisandra chinensis extractSCE groups, the high-dose SCE group showed

a decreasing tendency compared to the TC group. 


However, erythrocyte SOD activity showed a significant increase in the low-dose SCE group compared with the TC 

group. On the other hand, no significant differences in hepatic total glutathione (GSH) level, glutathione 

reductase (GR), and glutathione peroxidase (GSH-Px) activities were observed among the TC and SCE groups. 

Hepatic histopathological evaluation revealed that pretreatment with SCE resulted in reduced t-BHP-induced 

incidence of lesions, such as neutrophil infiltration, swelling of liver cells, and necrosis. 


In particular, treatment with a high dose of SCE resulted in induction of phase II antioxidant/detoxifying 

enzyme expression, such as glutathione S-transferase (GST) and glutamate-cysteine ligase catalytic subunit 

(GCLC). CONCLUSIONS: Based on these results, we conclude that SCE exerts protective effects against t-BHP 

induced oxidative hepatic damage through the reduction of neutrophil infiltration, swelling of liver cells, 

and necrosis. In addition, Schisandra chinensis extractSCE regulates the gene expression of phase II 

antioxidant/detoxifying enzymes independent of hepatic antioxidant enzyme activity.