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Metabolomics analysis reveals variation in Schisandra chinensis extract cetabolites from different origins.

Date:2016/8/30 23:27:54

Metabolomics analysis reveals variation in Schisandra chinensis extract cetabolites from different origins. 

Wu Wei Zi (Schisandra chinensis extract), an important herbal medicine, is mainly distributed in the northeast 

of China. Its phytochemical compositions, which depend on geographical origin, climatic conditions and cultural 

practices, may vary largely among Wu Wei Zi(Schisandra chinensis extract) from different areas. 


In this study, we applied a comprehensive metabolite profiling approach using GC-TOF-MS, ultra-performance 

liquid chromatography (UPLC) quadrupole time-of-flight (Q-TOF) MS and inductively coupled plasma MS (ICP-MS) 

to systematically investigate the metabolite variations of Schisandra chinensis extract from four different 

areas including Heilongjiang, Liaoning, Jilin and Shanxi of China. A total of 65 primary metabolites, 35 secondary 

metabolites and 64 inorganic elements were identified. Several primary metabolites, including shikimic acid and 

tricarboxylic acid cycle intermediates, were abundant in those located in Heilongjiang, Jilin and Liaoning. 


Besides, bioactive lignans are also highly abundant in those from northeastern China than those from northwestern 

China. Inorganic elements varied significantly among the different locations. Our results suggested that the 

metabolite profiling approach using GC-TOF-MS, UPLC-QTOF-MS and ICP-MS is a robust and reliable method that can

be effectively used to explore subtle variations among plants from different geographical locations. 

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