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Effects of Schisandra chinensis extracts on cough and pulmonary inflammation in a cough hypersensitivity guinea pig model induced by cigarette smoke exposure

Date:2016/8/30 23:11:01

Effects of Schisandra chinensis extracts on cough and pulmonary inflammation in a cough hypersensitivity guinea 

pig model induced by cigarette smoke exposure.Schisandra chinensis extract(S.chinensis) is a traditional Chinese 

medicine commonly used in prescription medications for the treatment of chronic cough. However, the material 

basis of S.chinensis in relieving cough has not been completely elucidated yet. 


This study established a guinea pig model of cough hypersensitivity induced by 14 days of cigarette smoke (CS) 

exposure, to evaluate the antitussive, antioxidant, and anti-inflammatory effects of three Schisandra chinensis extracts.

And then the function of four lignans in reducing expression of TRPV1 and TRPA1 was examined using A549 cells 

induced by cigarette smoke extract (CSE). The results demonstrated that both ethanol extract (EE) and ethanol-water 

extract (EWE) of S.chinensis, but not water extract (WE), significantly reduced the cough frequency enhanced by 

0.4M citric acid solution in these cough hypersensitivity guinea pigs. Meanwhile, pretreatment with EE and EWE 

both significantly attenuated the CS-induced increase in infiltration of pulmonary neutrophils and total inflammatory 

cells, as well as pulmonary MDA, TNF-伪, and IL-8, while remarkably increased activities of pulmonary SOD and GSH. 


According to H&E and immunofluorescence staining assays, airway epithelium hyperplasia, smooth muscle thickening, 

inflammatory cells infiltration, as well as expression of TRPV1 and TRPA1, were significantly attenuated in animals 

pretreatment with 1g/kg EE. Moreover, four lignans of EE, including schizandrin, schisantherin A, deoxyschizandrin 

and schisandrin, significantly inhibited CSE-induced expression of TRPV1, TRPA1 and NOS3, as well as NO release 

in A549 cells. In conclusion, S.chinensis reduces cough frequency and pulmonary inflammation in the CS-induced 

cough hypersensitivity guinea pigs. Lignans may be the active components. Copyright 2015. Published by Elsevier 

Ireland Ltd.