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Gender-dependent pharmacokinetics of lignans in rats after single and multiple oral administration of Schisandra chinensis extract

Date:2016/8/29 21:09:27

Gender-dependent pharmacokinetics of lignans in rats after single and multiple oral administration of Schisandra 

chinensis extract. Schisandra chinensis extract, a traditional Chinese medicine, has been widely used as 

sedatives and tonics in clinic. Schisandra lignans are believed to be the major bioactive components in Schisandra 

chinensis Extract. 


However, there is a lack of information about the effects of gender and repeated-dose on the pharmacokinetic 

properties of the schisandra lignans.The study was performed to investigate the influence of gender on the 

pharmacokinetics of schisandra lignans after administration of S. chinensis extract and to compare their pharmacokinetic 

behaviors between single and multiple administration.Two groups of rats (half male and half female) were received 

a single dose or multiple doses of Schisandra chinensis extract, respectively. 


A liquid chromatography-tandem mass spectrometry method was developed and validated to determine the plasma 

concentrations of schisandra lignans.The pharmacokinetic parameters of schisandrin, schisandrol B, deoxyschisandrin, 

schisandrin and schisantherin A were significantly different by gender difference. The t1/2 of all the tested 

schisandra lignans in female rats were 2-9 times longer than the corresponding values in male rats. 


The Cmax and AUC0-t of these schisandra lignans except schisantherin A in female rats were 5-50 times higher 

than those in male rats. The pharmacokinetic profiles of schisandrin, schisandrol B, deoxyschisandrin and 

schisantherin A in both gender rats after multiple doses were similar to the corresponding profile after single 

dose.All the tested schisandra lignans showed slower elimination and higher bioavailability in female rats after 

single or multiple administration of S. chinensis extract compared with male rats. Their pharmacokinetic profiles 

were not affected by repeated-dose except schisandrin, which was eliminated more slowly in female rats after 

multiple administration.