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Enrichment and purification of deoxyschizandrin and γ-schizandrin from the Schisandra chinensis extract fruit by macroporous resins

Date:2016/8/29 21:01:16

Enrichment and purification of deoxyschizandrin and γ-schizandrin from the Schisandra chinensis extract

fruit by macroporous resins. In present study, the performance and separation characteristics of 21 macroporous 

resins for the enrichment and purification of deoxyschizandrin and schizandrin, the two major lignans from 

Schisandra chinensis extracts, were evaluated. 


According to our results, HPD5000, which adsorbs by the molecular tiers model, was the best macroporous resin, 

offering higher adsorption and desorption capacities and higher adsorption speed for deoxyschizandrin and 

schizandrin than other resins. Columns packed with HPD5000 resin were used to perform dynamic adsorption and 

desorption tests to optimize the technical parameters of the separation process. The results showed that the 

best adsorption time is 4 h, the rate of adsorption is 0.85 mL/min (4 BV/h) and the rate of desorption is 

0.43 mL/min (2 BV/h). After elution with 90% ethanol, the purity of deoxy-schizandrin increased 12.62-fold from 

0.37% to 4.67%, the purity of schizandrin increased 15.8-fold from 0.65% to 10.27%, and the recovery rate was

 more than 80%.