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Schisandra chinensis extract has effects on gastrointestinal motility in mice.

Date:2015/12/15 9:40:36

Effects of schisandra chinensis extract on gastrointestinal motility in mice

Schisandra chinensis extract continues to be used as a traditional folk medicine in Asia, especially for the treatment of gastrointestinal (GI) disorders related to gastritis, diarrhea, enterocolitis and abnormal GI motility.

Why does schisandra chinensis extract  have such efficacy?

Because GI disorders, especially abnormal GI motility are major lifelong problems, we investigated the effects of schisandra chinensis extract on the pacemaker activity of the interstitial cells of Cajal (ICCs) in murine small intestine and GI motility.Enzymatic digestions were used to dissociate ICCs from small intestines, and the whole-cell patch-clamp configuration was used to record potentials generated by cultured ICCs.Effects of schisandra chinensis extract on GI motility were investigated by measuring the intestinal transit rate (ITR) of evans blue in normal and GI motility dysfunction mice.

schisandra chinensis extracts depolarized the membrane potentials of ICCs in a dose dependent manner. Pretreatment with Cafree solution or thapsigargin (a Ca-ATPase inhibitor in the endoplasmic reticulum) abolished the generation of pacemaker potentials by ICCs, and under these conditions, schisandra chinensis extract did not depolarize the membrane potentials of ICCs. In addition, membrane depolarizations were inhibited by intracellular GDPS and by U-73122 (an active phospholipase C (PLC) inhibitor). In normal mice, ITRs were significantly increased by schisandra chinensis extract  in a dose dependent manner. Also, schisandra chinensis extract significantly recovered the GI motility dysfunctions in acetic acid (AA)-injected and streptozotocin (STZ)-induced diabetic mice, which are the GI motility animal models.

schisandra chinensis extract modulates pacemaker potentials in ICCs in a dose dependent mannerexternal and internal Caregulations, andG protein and the PLC pathway. In addition, schisandra chinensis extract increased ITRs in normal and abnormal GI motility mice models. This study shows that SC extract offers a basis for the development of a prokinetic agent that prevents or alleviates GI motility dysfunctions.