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Inhibitory effects of Schisandra chinensis extract on acne-related inflammation and UVB-induced photoageing.

Date:2016/8/22 21:05:58

Inhibitory effects of Schisandra chinensis extract on acne-related inflammation and UVB-induced photoageing.

Schisandra chinensis (Turcz.) Baill. (Schisandraceae) fruit extract (SFE) has been reported to induce non-specific 

tissue protection against inflammation in vivo. However, the effects of SFE on Propionibacterium acnes-stimulated 

acne and UVB-irradiated photoageing have yet to be investigated. OBJECTIVE: To systematically investigate the 

effects of SFE against P. acnes and photoageing in vitro. MATERIALS AND METHODS: Qualitative and quantitative 

analyses of SFE were performed by HPLC. SFE concentrations from 2.5 to 5065μg/mL were tested. Specifically, 

ELISA was used to examine the levels of pro-inflammatory cytokines in THP-1 cells as well as of collagen I and 

matrix metalloproteinases-1 in HDF cells. The anti-bacterial effect of SFE was determined using the microdilution 

broth method. Glutathione and malondialdehyde levels were examined using the colorimetric and TBA methods, 

respectively. The degree of ageing was determined by cytochemical staining. RESULTS: SFE significantly inhibited 

P. acnes growth (MIC 0.565mg/mL) and 5065μg/mL of SFE suppressed the production of interleukin-1β, interleukin-8 

and tumour necrosis factor α, by 59.67%, 62.69% and 68.30%, respectively, in P. acnes-stimulated THP-1 cells. 

Additionally, 1065μg/mL of SFE suppressed photoageing in UVB-exposed fibroblasts by decreasing metalloproteinase 

levels by 88.4%, inducing collagen by 58.4% and activating the anti-oxidant defence system, by limiting lipid 

peroxidation by 51.1% and increasing glutathione production by 34.1% (2.565μg/mL SFE). 

DISCUSSION AND CONCLUSION: These results indicated that SFE could significantly ameliorate the inflammatory 

state in P. acnes-stimulated THP-1 and UVB-irradiated HDF cells, suggesting its potential as a novel agent for 

acne therapy and photoageing prevention.