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The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice.

Date:2016/8/23 10:29:29


The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and 

glutamatergic systems in the forced swim test in mice.Schisandra chinensis extracts(Turcz.) Baill., as a Chinese functional food, has been widely used in neurological disorders including insomnia and Alzheimer's disease. The treatment of classical neuropsychiatric disorder 

depression is to be developed from Schisandra chinensis extracts. The antidepressant-like effects of the Schisandra 

chinensis extracts (SCE), and their probable involvement in the serotonergic, noradrenergic, dopaminergic, 

GABAergic and glutamatergic systems were investigated by the forced swim test (FST). Acute administration of 

SCE (600 mg kg611, i.g.), a combination of SCE (300 mg kg611, i.g.) and reboxetine (a noradrenalin reuptake 

inhibitor, 2.5 mg kg611, i.p.) or imipramine (a TCA, 2 mg kg611, i.p.) reduced the immobility time in the FST.

 Pretreatment with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4, a selective noradrenergic 

neurotoxin, 50 mg kg611, i.p., 4 days), haloperidol (a non-selective D2 receptor antagonist, 0.2 mg kg611, i.p.),

 SCH 23390 (a selective D1 receptor antagonist, 0.03 mg kg611, i.p.), bicuculline (a competitive GABA antagonist,

 4 mg kg611, i.p.) and N-methyl-D-aspartic acid (NMDA, an agonist at the glutamate site, 75 mg kg611, i.p.) 

effectively reversed the antidepressant-like effect of SCE (600 mg kg611, i.g.). However, p-chlorophenylalanine

 (pCPA, an inhibitor of 5-HT synthesis, 100 mg kg611, i.p., 4 days,) did not eliminate the reduced immobility 

time induced by SCE (600 mg kg611, i.g.). 


Moreover, the treatments did not change the locomotor activity. 

Altogether, these results indicated that SCE produced antidepressant-like activity, which might be 

mediated by the modification of noradrenergic, dopaminergic, GABAergic and glutamatergic systems.