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Effect of the Schisandra chinensis extract Fruit and Morus alba Leaf on Insulin Secretion in Glucose-induced HIT-T15 Cells

Date:2016/9/30 14:39:06

Effect of the Schisandra chinensis extract Fruit and Morus alba Leaf on Insulin Secretion in Glucose-induced HIT-T15 Cells. This study aimed to examine the effect of the Schisandra chinensis extract fruit and Morus alba leaf on insulin expression in HIT-T15 cells, which is exposed by glucose. The total polyphenol contents of the Schisandra chinensis extract fruit ethanol extract and the M. alba leaf hot-water extract were mg/g and mg/mL, respectively. The S. chinensis fruit ethanol extract and the M. alba leaf hot-water extract contained and mg/g flavonoids, respectively. The antioxidant ability of the M. alba leaf hot-water extract was found to be superior to that of the S. chinensis fruit ethanol extract. Compared to the HIT-T15-treated 10 mM 2-deoxy-D-glucose, the Schisandra chinensis extract ethanol was found to have a two fold increase in insulin productivity. 


Moreover, the M. alba leaf hot-water extract promoted the insulin secretion of high-glucose-damaged HIT-T15 almost ten fold. The above results showed that the S. chinensis fruit ethanol extract and M. alba leaf hot-water extract may improve the insulin productivity of the beta cell with glucose-induced oxidative damage. These data suggest that the S. chinensis fruit ethanol extract and the M. alba leaf hot-water extract can be used as food materials for the regulation of insulin secretion.