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Acute Toxity and Protective Effects of Caulis of Schisandra chinensis Extracts on Liver Injury in Mice

Date:2016/9/27 21:43:42

Acute Toxity and Protective Effects of Caulis of Schisandra chinensis Extracts on Liver Injury in Mice

Objective:To evaluate the acute toxicity and the protective effects of the extraction from caulis of Schisandra chinensis Extracts on acute hepatic injury induced by carbon tetrachloride(CCl4) in mice.


Method:The maximum dosage(concentration 0.40 g•mL-1,dose 0.04 mL•g-1) of the extraction from caulis of Schisandra chinensis Extracts was used as ig administration in mice to measure the maximum tolerance dose(MTD).With different doses of the extracts(ig 3.03,4.55,9.09 g•kg-1),the levels of ALT and AST in serum were observed for acute liver injury induced by CCl4 in mice.


Result:The MTD of the extraction in mice was 32 g•kg-1•d-1.All dose groups of the extraction from caulis of Schisandra chinensis Extracts could decrease the levels of ALT and AST in serum.Compared with the model control group,moderate and high dose groups could significantly decrease the levels of ALT and AST in serum(P0.05,P0.01).


Conclusion:The extraction from caulis of Schisandra chinensis Extracts has low toxicity,and shows protective effect on acute liver injury induced by CCl4 in mice.