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Study on bactericidal and bacteriostatic effects of Schisandra chinensis extract fruit against Acinetobacter baumannii in vitro.

Date:2016/9/24 23:19:34

Study on bactericidal and bacteriostatic effects of Schisandra chinensis extract fruit against Acinetobacter baumannii 

in vitro.

Objective To observe the bactericidal and bacteriostatic effects of Schisandra chinensis extract fruit against 

Acinetobacter baumannii which was resistant to cefoperazone-sulbactam or non-resistant to cefoperazone-sulbactam.


Methods The Schisandra chinensis extract fruit was prepared,bacteriostatic and bactericidal test in vitro 

by tube double dilution method was performed to observe their minimal inhibitory concentration( MIC) and minimal 

bactericidal concentration( MBC) to Acinetobacter baumannii. Results The MIC50 of Schisandra chinensis fruit aga

inst Acinetobacter baumannii resistant to cefoperazone-sulbactam or non-resistant to cefoperazone-sulbactam were 

15. 6 and7. 8 mg /mL,and on this drug concentration,the inhibitory rate against non-resistant to cefoperazone-sulbactam 

Acinetobacter baumannii was higher than that against resistant to cefoperazone-sulbactam( 2= 4. 26 and 3. 98,P 

0. 05). When the drug concentration reached to 31. 3mg /mL,the inhibitory rates were all 100%. 


The MBC50 of Schisandra chinensis fruit against Acinetobacter baumannii which was resistant to cefoperazone-sulbactam 

or non-resistant to cefoperazone-sulbactam were 31. 3 mg /mL,and the bactericidal rate had no statistical 

significance( 2= 0. 74,P 0. 05). Conclusions The Schisandra chinensis fruit has certain bactericidal and 

bacteriostatic effects on Acinetobacter baumannii which was resistant to cefoperazone-sulbactam or non-

resistant to cefoperazone-sulbactam in vitro,and the MIC against Acinetobacter baumannii is a little higher. 


It suggests that Schisandra chinensis fruit could be used for the clinical treatment of Acinetobacter baumannii.