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Experimental Study on Isolation and Purification of Total Lignans from Schisandra Chinensis extract and the Antitumor Activity in Vitro.

Date:2016/9/23 21:10:27

Experimental Study on Isolation and Purification of Total Lignans from Schisandra Chinensis extract and the Antitumor Activity in Vitro.

To extract and purify total lignans from Schisandra chinensis extract and then investigate the inhibitory activity of the extracts on tumor in vitro.


Method:The total lignans from Schisandra chinensis extract were isolated and purified with diatomite-Soxhlet extraction method,and the inhibitory effect of the total lignans were investigated by MTT assay on MCF-7、HepG2 and 9706 in vitro.Result: The yield and content of total lignans was 17.7%and 11.7%,respectively.Significantly inhibitory activity was found in MCF-7、HepG2 malignant tumor cell lines.


Conclusion:Diatomite-Soxhlet extraction method is capable of extracting and purifying total lignans. The total lignans from Schisandra chinensis extract has the anti-tumor activity on tumor cell in vitro.