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Hepatoprotective effect of Schisandra chinensis extract (Turcz.) Baill. lignans and its formula with Rubus idaeus on chronic alcohol-induced liver injury in mice.

Date:2016/9/20 22:36:43

Hepatoprotective effect of Schisandra chinensis extract (Turcz.) Baill. lignans and its formula with Rubus 

idaeus on chronic alcohol-induced liver injury in mice. This study aimed to investigate the liver protection 

effect of (Turcz.) Baill. Schisandra chinensis extract and its combination with (RI) on chronic alcohol-induced

A low level of SC (SL) was prepared from the clear juice of sarcocarp. were further extracted from the Schisandra 

chinensis extract seeds and added to the SL to form high-level Schisandra chinensis extract (SH). 


Moreover, RI clear juice lyophilized powder was mixed with SL (SR), and the liver protection effects of SL, 

SH and SR were investigated. Male ICR were administered with the corresponding samples and gastrically infused 

with 50% alcohol (1 h later) once per day for 60 d. In the in vitro study, the characteristic in the Schisandra 

chinensis extract clear juice and the seed extract were analyzed by high performance liquid chromatography 

(HPLC). The total phenolic content (TPC) and capability of SL, SH, and SR were determined. 


The results of the in vivo study showed that SC exhibited a dose-dependent effect on the regulation of hepatic 

status, serum transaminases levels, and hepatic fat deposition in . However, hepatic lesions were observed in 

the SH , which indicated a potential side effect caused by long-term consumption of SH under chronic alcohol 

administration. By contrast, SR exhibited a similar hepatoprotective effect as SH without any abnormality found 

in the histological analysis. After analysis with HPLC, Schizandrol A and Schizandrol B were identified in the 

Schisandra chinensis extract clear juice, and two more kinds of , Schisandrin A and Schisandrin B, were 

identified in the seed extracts. The SR sample had the highest TPC and exhibited the best capability. 


In conclusion, RI strengthened the liver protection effect of SC effectively and safely, which was probably 

achieved by enhancing the status and the positive effect of their combination was possibly attributed to both 

and . This study demonstrated that the combination of low-level SC and RI might be used as a potential safe 

formula for beverage to alleviate the adverse effects of long-term alcohol consumption.