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Supercritical fluid extraction of lignans and cinnamic acid from Schisandra chinensis extract.

Date:2016/9/19 20:59:50

Supercritical fluid extraction of lignans and cinnamic acid from Schisandra chinensis extract.Biologically 

active lignans from caulomas (stems) and leaves of Schisandra chinensis extract were extracted with 

supercritical carbon dioxide at the pressures 20–2702MPa, temperatures 40, 50 and 6002°C, and solvent-to-feed

ratio 36–43. Six major lignans were determined by means of HPLC: schizandrin, gomisin A, deoxyschizandrin, 

γ-schizandrin, gomisin N and wuweizisu C. At the optimum conditions 2702MPa and 5002°C, the extraction yield 

of lignans from caulomas was 1.3% dry weight and their content in the extract was higher than 3202wt.%. 


At the optimum conditions for CO 2 extraction from S. chinensis leaves, 2702MPa and 6002°C, the yield of 

lignans was 0.22% d.w. and the yield of ( E )-cinnamic acid was 0.18% d.w. Addition of 2–4% ethanol to CO 2 

increased the extraction rate but not the final yield of lignans. The solubility of extracted substances in 

supercritical CO 2 was estimated from their Schisandra chinensis extract rates.