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Schisandrin B from Schisandra chinensis extract reduce hepatic lipid contents in hypercholesterolaemic mice

Date:2016/9/12 22:50:33

Schisandrin B from Schisandra chinensis extract reduce hepatic lipid contents in hypercholesterolaemic mice

The effects of schisandrin B (Sch B) on liver and serum lipid contents were investigated in mice with experimentally-

induced hypercholesterolaemia. Hypercholesterolaemia was induced either by oral administration of a cholesterol/

bile salts mixture (2/0.5 g kg(-1)) for four days or by feeding a high fat/cholesterol/bile salts (10/1/0.3%, w/w) 

diet for seven days. Daily co-administration of Sch B (50-200 mg kg(-1), i.g.) for four or six days, respectively, 

decreased hepatic total cholesterol (TC) and triglyceride (TG) levels (by up to 50% and 52%, respectively) in 

hypercholesterolaemic mice. Sch B treatment also increased hepatic indices (14-84%) in hypercholesterolaemic 

mice. 

The results indicated that Sch B treatment could decrease hepatic TC and TG levels, and increase liver weight, 

in mouse models of hypercholesterolaemia. Fenofibrate treatment (100 mg kg(-1)) produced effects similar to 

those of Sch B on the hepatic index and lipid levels of hypercholesterolaemic mice.