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Dibenzocyclooctadiene lignans from Schisandra chinensis extract protect primary cultures of rat cortical cells from glutamate-induced toxicity.

Date:2016/9/12 22:42:49

Dibenzocyclooctadiene lignans from Schisandra chinensis extract protect primary cultures of rat cortical cells 

from glutamate-induced toxicity. A methanolic extract of dried Schisandra fruit (Schisandra chinensis extract 

Baill.; Schisandraceae) significantly attenuated the neurotoxicity induced by L-glutamate in primary cultures 

of rat cortical cells. 


Five dibenzocyclooctadiene lignans (deoxyschisandrin, gomisin N, gomisin A, schisandrin, and wuweizisu C) were 

isolated from the methanolic extract; their protective effects against glutamate-induced neurotoxicity were 

then evaluated. Among the five lignans, deoxyschisandrin, gomisin N, and wuweizisu C significantly attenuated 

glutamate-induced neurotoxicity as measured by 1). an inhibition in the increase of intracellular [Ca(2+)]; 2).

an improvement in the glutathione defense system, the level of glutathione, and the activity of glutathione 

peroxidase; and 3). an inhibition in the formation of cellular peroxide. These results suggest that dibenzocyclooctadiene 

lignans from Schisandra chinensis extract may possess therapeutic potential against oxidative neuronal damage 

induced by excitotoxin. Copyright 2004 Wiley-Liss, Inc.