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Effects of Extract of Schisandra chinensis extract Baill on Clopidogrel Pharmacokinetic for Rats

Date:2016/9/11 23:49:21

Effects of Extract of Schisandra chinensis extract Baill on Clopidogrel Pharmacokinetic for Rats. 

Objective: This study is to investigate the effects of Schisandra chinensis extract Baill on Clopidogrel's pharmacokinetic 

for rats. Methods: Eighteen Sprague-Dawley rats were randomly divided into 3 groups( n = 6) : Group C( Clopidogrel 

without Schisandra chinensis extract Baill),Group CS1( Clopidogrel with Schisandra chinensis extract Baill poured for 1 

time) and Ggroup CS6( Clopidogrel with Schisandra chinensis extract Baill poured for 6 days). In Group C,rats 

were fasted for 12 h. While in Group CS1,2. 4 mg kg-1of the Schisandra chinensis extract Baill was given 

orally for 1 time after the rats were fasted for 12 h. And in Group CS6,after the rats were fasted for 12 h.,2. 4 mg 

kg-1of the Schisandra chinensis extract Baill was given orally for 6 days. Then all the rats were given 

30 mg kg-1Clopidogrel orally. Blood samples were taken from the tail vein at multipoints after gavage for determination 

of plasma SR26334 concentration by HPLC. The pharmacokinetic parameters of three groups were calculated by Drug 

And Statistics soft version 2. 0. Then Group C and GroupCS1,Group C and Group CS6 were comparable with respect 

to pharmacokinetic parameters. Results: No differences between Group C and Group CS1 in Cmax,AUC( 0-t),AUC( 0-1),Clz/F,

T max and t 1 /2z were found( P 0. 05). AUC( 0-t)  AUC( 0-1),C max of SR26334 in Group CS6 was significantly lower 

than that in Group C( P 0. 05). Clz / F of SR26334 in Group CS6 was significantly higher than that in Group C( P 0.

 05). Also there was no difference between Group CS6 and Group C in T max and t 1 /2z( P 0. 05). 


Conclusion: When Schisandra chinensis extract Baill and Clopidogrel are both used in rats for one time,Schisandra 

chinensis extract Baill can not influence the pharmacokinetics of Clopidogrel. But for a long time,Schisandra 

chinensis extract Baill reduce AUC and Cmax of Clopidogrel's carboxylic acid metabolite SR26334. When both two 

drugs are used in clinical application for a long time,the dosage of Clopidogrel should be restricted,and the 

pharmaceutical care of Clopidogrel should be enhanced.