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Schisandra chinensis extract Baill, a Chinese medicinal herb, alleviates high-fat-diet-inducing non-alcoholic steatohepatitis in rats.

Date:2016/9/11 23:44:02

Schisandra chinensis extract Baill, a Chinese medicinal herb, alleviates high-fat-diet-inducing non-alcoholic 

steatohepatitis in rats. he present study aims to explore whether Schisandra chinensis extract Baill, a Chinese,

medicinal herb can alleviates high-fat-diet-inducing non-alcoholic steatohepatitis in rats.In the study, 24, 

male Wister rats with body weight between 180-220g, were included. The rats were randomly divided into four 

groups: model group, normal control group, rosiglitazone group, and Schisandra chinensis extract Baill group. 


The treatment lasted for 56, days. The high-fat diet used in the present study includes 25% lard, 2%, cholesterol 

0.5%, sodium cholate, and 25%, Tween-80. The hepatic levels of superoxide dismutase (SOD), and malondialdehyde 

(MDA); the serum levels of total cholesterol (TC), and low-density lipoprotein cholesterol (LDLC), were detected.

We found that the hepatic levels of SOD were significantly lower, and the serum levels of TC, LDLC as well as, 

the hepatic levels of MDA in model group were significantly higher than those of normal control group; rosiglitazone 

group and Schisandra chinensis extract Baill group (P0.05).It is then concluded that Schisandra chinensis extract Baill can significantly allevi

ate the non-alcoholic steatohepatitis of the rats induced by high-fat diet, and it may be used as a complementary 

therapy for rosiglitazone